The entry of remnants of cholesterol-rich lipoproteins, such as low-density lipoprotein (LDL), from the blood stream into the intima of large arteries initiates and then perpetuates atherosclerosis. A study published in Nature sheds new light on this important process by identifying scavenger receptor BI (SR-BI) as a major receptor that mediates LDL delivery across the endothelium into arteries.
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Zhang, X., Fernández-Hernando, C. The Janus-faced role of SR-BI in atherosclerosis. Nat Metab 1, 586–587 (2019). https://doi.org/10.1038/s42255-019-0072-5
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DOI: https://doi.org/10.1038/s42255-019-0072-5
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Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics
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