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The Janus-faced role of SR-BI in atherosclerosis

The entry of remnants of cholesterol-rich lipoproteins, such as low-density lipoprotein (LDL), from the blood stream into the intima of large arteries initiates and then perpetuates atherosclerosis. A study published in Nature sheds new light on this important process by identifying scavenger receptor BI (SR-BI) as a major receptor that mediates LDL delivery across the endothelium into arteries.

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The authors declare no competing interests.

Correspondence to Carlos Fernández-Hernando.

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Fig. 1: The yin and yang of SR-B1 in atherogenesis.