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IRON HOMEOSTASIS

Radical sensing keeps noxious iron at bay

Living organisms face the dual challenge of acquiring enough iron to perform biological functions while preventing toxic iron accretion. A study now shows that sensing of iron-catalysed free radicals by a druggable gene-regulatory pathway helps the body avoid iron poisoning.

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Correspondence to Bruno Galy.

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Fig. 1: NRF2 links iron-induced oxidative stress to hepcidin.