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GPNMB: expanding the code for liver–fat communication

Interorgan communication is emerging as a critical contributor to nutrient and energy homeostasis. A new study has identified a secreted liver factor that stimulates lipid synthesis in white adipose tissue and exacerbates obesity and insulin resistance.

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References

  1. 1.

    Gong, X.-M. et al. Nat. Metab. https://doi.org/10.1038/s42255-019-0065-4 (2019).

  2. 2.

    Meex, R. C. R. & Watt, M. J. Nat. Rev. Endocrinol. 13, 509–520 (2017).

  3. 3.

    Kliewer, S. A. & Mangelsdorf, D. J. Cell Metab. 29, 246–253 (2019).

  4. 4.

    Wang, Q. et al. Nat. Metab. 1, 251–260 (2019).

  5. 5.

    Xiong, X. et al. Mol. Metab. 20, 128–137 (2019).

  6. 6.

    Ghorpade, D. S. et al. Nature 555, 673–677 (2018).

  7. 7.

    Varin, E. M. et al. Cell Metab. 29, 320–334.e325 (2019).

  8. 8.

    Hashimoto, O. et al. Cell Rep. 25, 1193–1203 (2018).

  9. 9.

    van der Lienden, M. J. C., Gaspar, P., Boot, R., Aerts, J. & van Eijk, M. Int. J. Mol. Sci. 20, E66 (2018).

  10. 10.

    Gabriel, T. L. et al. Diabetes 63, 3310–3323 (2014).

  11. 11.

    Katayama, A. et al. Sci. Rep. 5, 16920 (2015).

  12. 12.

    Martinez-Santibañez, G. & Lumeng, C. N. Annu. Rev. Nutr. 34, 57–76 (2014).

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Correspondence to Jiandie D. Lin.

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Fig. 1: A novel hepatokine mediates hepatic–adipose endocrine signalling.