Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

TYPE 1 DIABETES

Divide and hide: proliferating β-cells control immune tolerance in autoimmune diabetes

Nature Metabolism volume 1, pages 499–500 (2019)Cite this article

Subjects

Increasing pancreatic β-cell proliferation in autoimmune type 1 diabetes (T1D) might restore β-cell mass but would be predicted to exacerbate islet inflammation. A study in Nature Metabolism, however, reports that boosting β-cell proliferation in mouse models of T1D is beneficial, preserving the immunological self-tolerance of islets through the induction of regulatory T cells.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Highly proliferative β-cells from LIRKO mice show altered identity, induce Treg cells and protect mice from the development of T1D.

References

  1. DiMeglio, L. A., Evans-Molina, C. & Oram, R. A. Lancet 391, 2449–2462 (2018).

    Article  Google Scholar 

  2. Imperatore, G. et al. Diabetes Care 35, 2515–2520 (2012).

    Article  Google Scholar 

  3. Herold, K. C., Vignali, D. A., Cooke, A. & Bluestone, J. A. Nat. Rev. Immunol. 13, 243–256 (2013).

    Article  CAS  Google Scholar 

  4. Spence, A., Klementowicz, J. E., Bluestone, J. A. & Tang, Q. Curr. Opin. Immunol. 37, 11–20 (2015).

    Article  CAS  Google Scholar 

  5. Roep, B. O., Wheeler, D. C. S. & Peakman, M. Lancet Diabetes Endocrinol. 7, 65–74 (2019).

    Article  Google Scholar 

  6. Dirice, E. et al. Nat. Metab. https://doi.org/10.1038/s42255-019-0061-8 (2019).

    Article  Google Scholar 

  7. Michael, M. D. et al. Mol. Cell 6, 87–97 (2000).

    Article  CAS  Google Scholar 

  8. Rui, J. et al. Cell Metab. 25, 727–738 (2017).

    Article  CAS  Google Scholar 

  9. De Rosa, V. et al. Nat. Immunol. 16, 1174–1184 (2015).

    Article  Google Scholar 

  10. De Rosa, V., La Cava, A. & Matarese, G. Nat. Immunol. 18, 1190–1196 (2017).

    Article  Google Scholar 

  11. Wang, P. et al. Cell Metab. 29, 638–652.e5 (2019).

    Article  CAS  Google Scholar 

  12. Cheng, C. W. et al. Cell 168, 775–788.e12 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Istituto per l’Endocrinologia e l’Oncologia Sperimentale del Consiglio Nazionale delle Ricerche (IEOS-CNR), Naples, Italy

    Mario Galgani & Giuseppe Matarese

  2. Treg Cell Lab, Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Università di Napoli Federico II, Naples, Italy

    Giuseppe Matarese

Authors
  1. Mario Galgani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Giuseppe Matarese
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Giuseppe Matarese.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Galgani, M., Matarese, G. Divide and hide: proliferating β-cells control immune tolerance in autoimmune diabetes. Nat Metab 1, 499–500 (2019). https://doi.org/10.1038/s42255-019-0068-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s42255-019-0068-1

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing