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OBESITY AND DIABETES

Hyaluronan as a potential thermogenic rheostat

Obesity is a manifestation of a positive energy balance in which energy intake exceeds energy expenditure, thus often leading to insulin resistance and type 2 diabetes. A new study provides evidence that pharmacological inhibition of hyaluronan, an extracellular-matrix glycosaminoglycan, increases energy expenditure and insulin sensitivity by activating thermogenesis in brown adipose tissue.

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Correspondence to Philip L. S. M. Gordts or Alan R. Saltiel.

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Fig. 1: Model for hyaluronan-mediated control of non-shivering thermogenesis.