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OBESITY AND DIABETES

Hyaluronan as a potential thermogenic rheostat

Nature Metabolism volume 1, pages 503–504 (2019)Cite this article

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Obesity is a manifestation of a positive energy balance in which energy intake exceeds energy expenditure, thus often leading to insulin resistance and type 2 diabetes. A new study provides evidence that pharmacological inhibition of hyaluronan, an extracellular-matrix glycosaminoglycan, increases energy expenditure and insulin sensitivity by activating thermogenesis in brown adipose tissue.

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Fig. 1: Model for hyaluronan-mediated control of non-shivering thermogenesis.

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Authors and Affiliations

  1. Department of Medicine, Division of Metabolism and Endocrinology, University of California, San Diego, La Jolla, CA, USA

    Philip L. S. M. Gordts & Alan R. Saltiel

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  1. Philip L. S. M. Gordts
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  2. Alan R. Saltiel
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Correspondence to Philip L. S. M. Gordts or Alan R. Saltiel.

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The authors declare no competing interests.

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Gordts, P.L.S.M., Saltiel, A.R. Hyaluronan as a potential thermogenic rheostat. Nat Metab 1, 503–504 (2019). https://doi.org/10.1038/s42255-019-0058-3

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