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A question of identity: Tbx3 carries the POMC flag

Nature Metabolismvolume 1pages175176 (2019) | Download Citation

Hypothalamic neuronal diversity is at the core of whole-body energy-homeostasis control, but the molecular mechanisms governing neuronal neuropeptide specification remain incompletely understood. A new study in Nature Metabolism adds a relevant piece to the puzzle of how key hypothalamic neuronal populations maintain their peptidergic identity throughout the lifespan.

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A.O. is supported by the Beatriu de Pinós programme from the Generalitat de Catalunya. M.C. is supported as a recipient of a Miguel Servet 2 contract (MSII15/00025) from Instituto de Salud Carlos III and is cofinanced by Fondo Europeo de Desarrollo Regional (FEDER), Unión Europea, ‘Una manera de hacer Europa’.

Author information


  1. Neuronal Control of Metabolism Laboratory, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

    • Arnaud Obri
    •  & Marc Claret
  2. Centro de Investigación Biomédica en Red (CIBER) de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

    • Marc Claret


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Competing interests

The authors declare no competing interests.

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Correspondence to Marc Claret.

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