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NEUROSCIENCE

A question of identity: Tbx3 carries the POMC flag

Nature Metabolism volume 1, pages 175–176 (2019)Cite this article

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Hypothalamic neuronal diversity is at the core of whole-body energy-homeostasis control, but the molecular mechanisms governing neuronal neuropeptide specification remain incompletely understood. A new study in Nature Metabolism adds a relevant piece to the puzzle of how key hypothalamic neuronal populations maintain their peptidergic identity throughout the lifespan.

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Fig. 1: Tbx3 is required for the terminal specification of POMC neurons.

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Acknowledgements

A.O. is supported by the Beatriu de Pinós programme from the Generalitat de Catalunya. M.C. is supported as a recipient of a Miguel Servet 2 contract (MSII15/00025) from Instituto de Salud Carlos III and is cofinanced by Fondo Europeo de Desarrollo Regional (FEDER), Unión Europea, ‘Una manera de hacer Europa’.

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Authors and Affiliations

  1. Neuronal Control of Metabolism Laboratory, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

    Arnaud Obri & Marc Claret

  2. Centro de Investigación Biomédica en Red (CIBER) de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Barcelona, Spain

    Marc Claret

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  1. Arnaud Obri
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  2. Marc Claret
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Correspondence to Marc Claret.

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Obri, A., Claret, M. A question of identity: Tbx3 carries the POMC flag. Nat Metab 1, 175–176 (2019). https://doi.org/10.1038/s42255-018-0027-2

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