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A question of identity: Tbx3 carries the POMC flag

Hypothalamic neuronal diversity is at the core of whole-body energy-homeostasis control, but the molecular mechanisms governing neuronal neuropeptide specification remain incompletely understood. A new study in Nature Metabolism adds a relevant piece to the puzzle of how key hypothalamic neuronal populations maintain their peptidergic identity throughout the lifespan.

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  1. 1.

    Timper, K. & Brüning, J. C. Dis. Model Mech. 10, 679–689 (2017).

  2. 2.

    Toda, C., Santoro, A., Kim, J. D. & Diano, S. Annu. Rev. Physiol. 79, 209–236 (2017).

  3. 3.

    Krude, H. et al. Nat. Genet. 19, 155–157 (1998).

  4. 4.

    Yaswen, L., Diehl, N., Brennan, M. B. & Hochgeschwender, U. Nat. Med. 5, 1066–1070 (1999).

  5. 5.

    Alvarez-Bolado, G. Cell Tissue Res. (2018).

  6. 6.

    Schneeberger, M. et al. Mol. Metab. 2, 74–85 (2012).

  7. 7.

    Greenman, Y. et al. Mol. Endocrinol. 27, 1091–1102 (2013).

  8. 8.

    Quarta, C. et al. Nat. Metab. (2019)

  9. 9.

    Willmer, T., Cooper, A., Peres, J., Omar, R. & Prince, S. Biosci. Trends 11, 254–266 (2017).

  10. 10.

    Luquet, S., Perez, F. A., Hnasko, T. S. & Palmiter, R. D. Science 310, 683–685 (2005).

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A.O. is supported by the Beatriu de Pinós programme from the Generalitat de Catalunya. M.C. is supported as a recipient of a Miguel Servet 2 contract (MSII15/00025) from Instituto de Salud Carlos III and is cofinanced by Fondo Europeo de Desarrollo Regional (FEDER), Unión Europea, ‘Una manera de hacer Europa’.

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Correspondence to Marc Claret.

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Fig. 1: Tbx3 is required for the terminal specification of POMC neurons.