News & Views | Published:


Go with the flow—hidden vascular passages in bone

Nature Metabolismvolume 1pages173174 (2019) | Download Citation

The circulatory system in long bones is incompletely understood. A new study published in Nature Metabolism unveils the presence of dense vascular networks in long bones that facilitate the egress of bone marrow cells and potentially the exchange of nutrients between the bone marrow and the systemic circulation.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    Grüneboom, A. et al. Nat. Metab. (2019).

  2. 2.

    Teitelbaum, S. L. Bone resorption by osteoclasts. Science 289, 1504–1508 (2000).

  3. 3.

    Stains, J. P. & Civitelli, R. Biochim. Biophys. Acta 1719, 69–81 (2005).

  4. 4.

    Herisson, F. et al. Nat. Neurosci. 21, 1209–1217 (2018).

  5. 5.

    Marinova-Mutafchieva, L., Williams, R. O., Funa, K., Maini, R. N. & Zvaifler, N. J. Arthritis Rheum. 46, 507–513 (2002).

  6. 6.

    Werner, D. et al. Arthritis Rheumatol. 69, 1580–1587 (2017).

  7. 7.

    Ortega-Gómez, A., Perretti, M. & Soehnlein, O. EMBO Mol. Med. 5, 661–674 (2013).

  8. 8.

    Ramasamy, S. K. et al. Nat. Commun. 7, 13601 (2016).

  9. 9.

    Nakashima, T. et al. Nat. Med. 17, 1231–1234 (2011).

  10. 10.

    Fullerton, J. N. & Gilroy, D. W. Nat. Rev. Drug Discov. 15, 551–567 (2016).

Download references

Author information


  1. Allergy, Immunology and Rheumatology Division, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA

    • Christopher Ritchlin
  2. Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA, USA

    • Iannis E. Adamopoulos
  3. Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children Northern California, Sacramento, CA, USA

    • Iannis E. Adamopoulos


  1. Search for Christopher Ritchlin in:

  2. Search for Iannis E. Adamopoulos in:

Competing interests

I.A. has received consultancy fees/grants from Pfizer, Schering-Plough/Merck, Tanabe Research Labs, and Novartis. C.R. declares no competing interests.

Corresponding author

Correspondence to Christopher Ritchlin.

About this article

Publication history



Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing