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Go with the flow—hidden vascular passages in bone

Nature Metabolismvolume 1pages173174 (2019) | Download Citation

The circulatory system in long bones is incompletely understood. A new study published in Nature Metabolism unveils the presence of dense vascular networks in long bones that facilitate the egress of bone marrow cells and potentially the exchange of nutrients between the bone marrow and the systemic circulation.

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References

  1. 1.

    Grüneboom, A. et al. Nat. Metab. https://doi.org/10.1038/s42255-018-0016-5 (2019).

  2. 2.

    Teitelbaum, S. L. Bone resorption by osteoclasts. Science 289, 1504–1508 (2000).

  3. 3.

    Stains, J. P. & Civitelli, R. Biochim. Biophys. Acta 1719, 69–81 (2005).

  4. 4.

    Herisson, F. et al. Nat. Neurosci. 21, 1209–1217 (2018).

  5. 5.

    Marinova-Mutafchieva, L., Williams, R. O., Funa, K., Maini, R. N. & Zvaifler, N. J. Arthritis Rheum. 46, 507–513 (2002).

  6. 6.

    Werner, D. et al. Arthritis Rheumatol. 69, 1580–1587 (2017).

  7. 7.

    Ortega-Gómez, A., Perretti, M. & Soehnlein, O. EMBO Mol. Med. 5, 661–674 (2013).

  8. 8.

    Ramasamy, S. K. et al. Nat. Commun. 7, 13601 (2016).

  9. 9.

    Nakashima, T. et al. Nat. Med. 17, 1231–1234 (2011).

  10. 10.

    Fullerton, J. N. & Gilroy, D. W. Nat. Rev. Drug Discov. 15, 551–567 (2016).

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Author information

Affiliations

  1. Allergy, Immunology and Rheumatology Division, Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, NY, USA

    • Christopher Ritchlin
  2. Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, Davis, CA, USA

    • Iannis E. Adamopoulos
  3. Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children Northern California, Sacramento, CA, USA

    • Iannis E. Adamopoulos

Authors

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  2. Search for Iannis E. Adamopoulos in:

Competing interests

I.A. has received consultancy fees/grants from Pfizer, Schering-Plough/Merck, Tanabe Research Labs, and Novartis. C.R. declares no competing interests.

Corresponding author

Correspondence to Christopher Ritchlin.

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DOI

https://doi.org/10.1038/s42255-018-0024-5

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