VASCULAR BIOLOGY

Endothelial metabolism—more complex (III) than previously thought

The growth of new blood vessels (angiogenesis) is a bio-energetically demanding process. Surprisingly, the specific role of mitochondria in angiogenesis remains unclear. A study in this issue of Nature Metabolism now demonstrates that mitochondrial respiration is essential for angiogenic growth by controlling endothelial proliferation.

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Fig. 1: Mitochondrial respiration supports endothelial proliferation.

References

  1. 1.

    Roger, A. J., Muñoz-Gómez, S. A. & Kamikawa, R. Curr. Biol. 27, R1177–R1192 (2017).

  2. 2.

    Palm, W. & Thompson, C. B. Nature 546, 234–242 (2017).

  3. 3.

    Vander Heiden, M. G., Cantley, L. C. & Thompson, C. B. Science 324, 1029–1033 (2009).

  4. 4.

    De Bock, K. et al. Cell 154, 651–663 (2013).

  5. 5.

    Potente, M. & Carmeliet, P. Annu. Rev. Physiol. 79, 43–66 (2017).

  6. 6.

    Diebold, L. P. et al. Nat. Metab. https://doi.org/10.1038/s42255-018-0011-x (2019).

  7. 7.

    Sullivan, L. B. et al. Cell 162, 552–563 (2015).

  8. 8.

    Birsoy, K. et al. Cell 162, 540–551 (2015).

  9. 9.

    Titov, D. V. et al. Science 352, 231–235 (2016).

  10. 10.

    Potente, M. & Mäkinen, T. Nat. Rev. Mol. Cell Biol. 18, 477–494 (2017).

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Correspondence to Michael Potente.

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Andrade, J., Potente, M. Endothelial metabolism—more complex (III) than previously thought. Nat Metab 1, 14–15 (2019). https://doi.org/10.1038/s42255-018-0019-2

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