The elusive NMN transporter is found

Strategies to restore levels of the enzyme cofactor nicotinamide adenine dinclueotide (NAD) late in life to maintain health by treatment with NAD precursors, such as nicotinamide mononucleotide (NMN), represent an exciting area of research in aging and age-related diseases. A study in Nature Metabolism provides an answer to the hotly debated yet fundamental question: how NMN actually gets into cells.

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  1. 1.

    Anderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O. & Sinclair, D. A. Nature 423, 181–185 (2003).

    CAS  Article  Google Scholar 

  2. 2.

    Zhang, H. et al. Science 352, 1436–1443 (2016).

    CAS  Article  Google Scholar 

  3. 3.

    Mills, K. F. et al. Cell Metab. 24, 795–806 (2016).

    CAS  Article  Google Scholar 

  4. 4.

    Massudi, H. et al. PLoS One 7, e42357 (2012).

    CAS  Article  Google Scholar 

  5. 5.

    Rajman, L., Chwalek, K. & Sinclair, D. A. Cell Metab. 27, 529–547 (2018).

    CAS  Article  Google Scholar 

  6. 6.

    Grozio, A. et al. N at. Metab. (2018).

  7. 7.

    Haffner, C. D. et al. J. Med. Chem. 58, 3548–3571 (2015).

    CAS  Article  Google Scholar 

  8. 8.

    Gerdts, J., Brace, E. J., Sasaki, Y., DiAntonio, A. & Milbrandt, J. Science 348, 453–457 (2015).

    CAS  Article  Google Scholar 

  9. 9.

    Katsyuba, E. et al. Nature 563, 354–359 (2018).

    CAS  Article  Google Scholar 

  10. 10.

    Trammell, S. A. et al. Nat. Commun. 7, 12948 (2016).

    CAS  Article  Google Scholar 

  11. 11.

    Ratajczak, J. et al. Nat. Commun. 7, 13103 (2016).

    CAS  Article  Google Scholar 

  12. 12.

    Daigle, N. D. et al. J. Cell. Physiol. 220, 680–689 (2009).

    CAS  Article  Google Scholar 

  13. 13.

    Gomes, A. P. et al. Cell 155, 1624–1638 (2013).

    CAS  Article  Google Scholar 

  14. 14.

    Trammell, S. A., Yu, L., Redpath, P., Migaud, M. E. & Brenner, C. J. Nutr. 146, 957–963 (2016).

    CAS  Article  Google Scholar 

  15. 15.

    Liu, L. et al. Cell Metab. 27, 1067–1080.e5 (2018).

    CAS  Article  Google Scholar 

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Correspondence to David A. Sinclair.

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Competing interests

L.W. is a is a founder, equity owner, advisor to, and/or director of Intravital, EdenRoc Sciences (Metro Biotech/Bauhaus, Liberty Biosecurity), Jumpstart Fertility, and Life Biosciences and its daughter companies (Continuum Biosciences, Jumpstart Fertility, Senolytic Therapeutics, Animal Biosciences, Selphagy, Spotlight Therapeutics). D.S. is a founder, equity owner, advisor to, director of, consultant to, and/or inventor of patents licensed to Jupiter Orphan Therapeutics, Cohbar, Galilei Biosciences, EdenRoc Sciences (Arc-Bio, Dovetail Genomics, Claret, Revere Biosciences, UpRNA, MetroBiotech/Bauhaus, Liberty Biosecurity), Life Biosciences (Selphagy, InsideTracker, Senolytic Therapeutics, Spotlight Therapeutics, Immetas, Animal Biosciences, Iduna, Continuum Biosciences, and Jumpstart Fertility), Wellomics, and Vium. MetroBiotech, Liberty Biosecurity, and Jumpstart are developing NAD boosting molecules/precursors for the treatment of diseases. D.S. is an inventor on an invention filed by Mayo Clinic and Harvard Medical School that has been licensed to Elysium Health. For more information see

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Wu, L.E., Sinclair, D.A. The elusive NMN transporter is found. Nat Metab 1, 8–9 (2019).

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