Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


The elusive NMN transporter is found

Strategies to restore levels of the enzyme cofactor nicotinamide adenine dinclueotide (NAD) late in life to maintain health by treatment with NAD precursors, such as nicotinamide mononucleotide (NMN), represent an exciting area of research in aging and age-related diseases. A study in Nature Metabolism provides an answer to the hotly debated yet fundamental question: how NMN actually gets into cells.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout


  1. Anderson, R. M., Bitterman, K. J., Wood, J. G., Medvedik, O. & Sinclair, D. A. Nature 423, 181–185 (2003).

    Article  CAS  Google Scholar 

  2. Zhang, H. et al. Science 352, 1436–1443 (2016).

    Article  CAS  Google Scholar 

  3. Mills, K. F. et al. Cell Metab. 24, 795–806 (2016).

    Article  CAS  Google Scholar 

  4. Massudi, H. et al. PLoS One 7, e42357 (2012).

    Article  CAS  Google Scholar 

  5. Rajman, L., Chwalek, K. & Sinclair, D. A. Cell Metab. 27, 529–547 (2018).

    Article  CAS  Google Scholar 

  6. Grozio, A. et al. N at. Metab. (2018).

  7. Haffner, C. D. et al. J. Med. Chem. 58, 3548–3571 (2015).

    Article  CAS  Google Scholar 

  8. Gerdts, J., Brace, E. J., Sasaki, Y., DiAntonio, A. & Milbrandt, J. Science 348, 453–457 (2015).

    Article  CAS  Google Scholar 

  9. Katsyuba, E. et al. Nature 563, 354–359 (2018).

    Article  CAS  Google Scholar 

  10. Trammell, S. A. et al. Nat. Commun. 7, 12948 (2016).

    Article  CAS  Google Scholar 

  11. Ratajczak, J. et al. Nat. Commun. 7, 13103 (2016).

    Article  CAS  Google Scholar 

  12. Daigle, N. D. et al. J. Cell. Physiol. 220, 680–689 (2009).

    Article  CAS  Google Scholar 

  13. Gomes, A. P. et al. Cell 155, 1624–1638 (2013).

    Article  CAS  Google Scholar 

  14. Trammell, S. A., Yu, L., Redpath, P., Migaud, M. E. & Brenner, C. J. Nutr. 146, 957–963 (2016).

    Article  CAS  Google Scholar 

  15. Liu, L. et al. Cell Metab. 27, 1067–1080.e5 (2018).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to David A. Sinclair.

Ethics declarations

Competing interests

L.W. is a is a founder, equity owner, advisor to, and/or director of Intravital, EdenRoc Sciences (Metro Biotech/Bauhaus, Liberty Biosecurity), Jumpstart Fertility, and Life Biosciences and its daughter companies (Continuum Biosciences, Jumpstart Fertility, Senolytic Therapeutics, Animal Biosciences, Selphagy, Spotlight Therapeutics). D.S. is a founder, equity owner, advisor to, director of, consultant to, and/or inventor of patents licensed to Jupiter Orphan Therapeutics, Cohbar, Galilei Biosciences, EdenRoc Sciences (Arc-Bio, Dovetail Genomics, Claret, Revere Biosciences, UpRNA, MetroBiotech/Bauhaus, Liberty Biosecurity), Life Biosciences (Selphagy, InsideTracker, Senolytic Therapeutics, Spotlight Therapeutics, Immetas, Animal Biosciences, Iduna, Continuum Biosciences, and Jumpstart Fertility), Wellomics, and Vium. MetroBiotech, Liberty Biosecurity, and Jumpstart are developing NAD boosting molecules/precursors for the treatment of diseases. D.S. is an inventor on an invention filed by Mayo Clinic and Harvard Medical School that has been licensed to Elysium Health. For more information see

Rights and permissions

Reprints and Permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Wu, L.E., Sinclair, D.A. The elusive NMN transporter is found. Nat Metab 1, 8–9 (2019).

Download citation

  • Published:

  • Issue Date:

  • DOI:



Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing