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Lnc-ing microRNA activity to atheroprotection

Cholesterol accumulation in cells and blood vessels promotes the development of vascular diseases. The long non-coding RNA CHROME can help clear excess cholesterol and provide protection from atherosclerosis.

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Fig. 1: Model for CHROME actions in atherosclerosis.


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Correspondence to Peter Tontonoz.

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Sallam, T., Tontonoz, P. Lnc-ing microRNA activity to atheroprotection. Nat Metab 1, 10–11 (2019).

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  • miRNAs
  • lncRNAs
  • ABCA1 Expression
  • High-density Lipoprotein Biogenesis
  • Carotid Artery Plaque


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