Jose R. Alonso and colleagues describe technical advances that will allow the proposed IsoDAR (isotope decay at rest) cyclotron — being developed for neutrino physics research — to produce many medical isotopes more efficiently than existing cyclotrons can.
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Schmor, P. Review of cyclotrons for the production of radioactive isotopes for medical and industrial applications. Rev. Accel. Sci. Technol. 4, 103–116 (2011).
Bungau, A. et al. Proposal for an electron antineutrino disappearance search using high-rate 8Li production and decay. Phys. Rev. Lett. 109, 141802 (2012).
Alonso, J. R. et al. Isotope production from the IsoDAR cyclotron. Preprint at arXiv https://arxiv.org/abs/1807.06627 (2018).
Calabretta, L., Rifuggiato, D. & Shchepounov, V. High intensity proton beams from cyclotrons for H2 +. IEEE https://accelconf.web.cern.ch/accelconf/p99/PAPERS/THP139.PDF (1999).
Conrad, J. MRI: development of the IsoDAR front-end. National Science Foundation https://www.nsf.gov/awardsearch/showAward?AWD_ID=1626069 (2017).
Miederer, M., Scheinberg, D. & DcDevitt, M. Realizing the potential of the actinium-225 radionuclide generator in targeted alpha-particle therapy applications. Adv. Drug Deliv. Rev. 60, 1371–1382 (2008).
Weidner, J. W. et al. Proton induced cross sections relevant to production of 225Ac and 223Ra in natural thorium targets below 200 MeV. Appl. Radiat. Isot. 70, 2602–2607 (2011).
The authors declare no competing interests.
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Alonso, J.R., Barlow, R., Conrad, J.M. et al. Medical isotope production with the IsoDAR cyclotron. Nat Rev Phys 1, 533–535 (2019). https://doi.org/10.1038/s42254-019-0095-6