The phenine concept delivers a nitrogen-doped nanotube and evokes infinite possibilities

Isobe et al. recently introduced the phenine concept, whereby a 1,3,5-trisubstituted benzene system (a phenine unit) is used as a basic building block instead of an sp2-hybridized carbon atom. Now, they apply it in a concise synthesis of a nitrogen-doped phenine nanotube.

Of course, no concept, no matter how clever it is, can be realized without reliable synthetic strategies and robust synthetic methodology behind it. Both of these qualities are strikingly evident in Isobe's synthesis. A natural consequence of the phenine concept is that most (if not all) C-C bonds formed in the synthesis of a phenine-expanded system are biaryl bonds. The availability of several highly effective transition metal-catalyzed cross-and homocoupling reactions thus provides a solid foundation for the development of general strategies. The synthesis of the (12,12)-NpNT was accomplished using a route that closely resembles the one employed earlier for the synthesis of the analogous all-carbon pNT 4 . This is by no means a case of the same old thing, but rather a testament to the strength of the overarching strategy.
The first stage of the synthesis was the five-step construction of a suitably decorated phenine-expanded benzene (3) from commercial 1-bromo-3-chlorobenzene (1) and 2,6-dibromopyridine (2) (the source of N atoms in the final product) (Fig. 2) 5 . The noteworthy features here are the use of the Marder borylation on two occasions to establish the key 1,3,5 substitution pattern and Suzuki-Miyaura and Yamamoto coupling reactions to stitch together the [6]cyclo-meta-phenylene structure. A Yamago-type platinacycle formation then gave rise to oligoarylene 4 after ligand exchange and reductive elimination. The yield for this twostep sequence was just 16%, but this should be weighed against what is accomplished: a giant macrocyclization to give an extraordinarily large oligoarylene (24 aromatic units). The remainder of the skeletal atoms were introduced using a two-step sequence consisting of iododesilylation and another Suzuki-Miyaura crosscoupling to afford 5. Considering that both transformations involve 16-fold reactions, the 59% yield over two steps is simply amazing (98.4% per reaction). The metamorphosis from nanoring to nanotube was then orchestrated through an 8-fold intramolecular Yamamoto coupling, which delivered the (12,12)-NpNT in 37% yield (88.3% per reaction). Compared to the synthesis of the previously reported pNT 4 , the overall yield improved by a factor of 2 (to 1.4%), which is meaningful in light of the large number of C-C bonds that were formed over the ten-step sequence. The spectacular performance of cross-coupling reactions (Suzuki-Miyaura, Yamago, Yamamoto) certainly bodes well for the construction of larger and even more elaborate systems.
A closer look at the synthesis of the (12,12)-NpNT through the lens of the phenine concept reveals that macrocycle 3 and the (12,12)-NpNT are phenine-expanded versions of compounds that have not yet been synthesized: [4]cyclo-para-phenylene and a Vögtle belt corresponding to a slice of a (4,4) carbon nanotube, respectively. Neither of these compounds would be expected to be at all stable and this has a fascinating implication. The phenine concept actually holds much more promise than was apparent at first glance. It has the potential to do more than just recreate what can be done using sp 2 -C building blocks. This point is reinforced by the presence of the eight N atoms in the (12,12)-NpNT structure. It is the first demonstration of the obvious, but important point that a phenine unit has the capacity to be modified chemically in a variety of ways, while an sp 2 -C atom does not. In addition to the advantages of size, flexibility and the potential for modification, the phenine building block comes with an intact Clar sextet as its π component, whereas an sp 2 -C building block comes with an unpaired electron in a p orbital (Fig. 3). Consequently, the assembly of sp 2 -C atoms can lead both to very favourable and very unfavourable π electronic situations, e.g., as in cyclobutadiene. This limitation is clearly absent when building with phenine units.
Focussing now on the molecule itself, Isobe's (12,12)-NpNT is a 40-arene behemoth with a molar mass of nearly 4000. It maps onto a (12,12) armchair carbon nanotube and has a length index of C x6 benzene phenine benzene sp 2 -hybridized carbon atom (methine unit) 1,3,5-trisubstituted benzene ring (phenine unit) t f = 7.0. It has exactly eight atom vacancy sites and eight methine units have been replaced with N atoms, quantitative measures of which are the atom-filling and bond-filling indices F a (64%) and F b (53%), respectively. Despite its great size, the exact structure was fully supported using the standard analytical tools of organic chemistry, including NMR, electronic absorption and fluorescence spectroscopy, mass spectrometry and X-ray crystallography. The latter technique deserves comment. Some very high level crystallography involving charge density methods (specifically, the use of the spherical independent atom model) was used to solve the crystal structure of the nanometer-long molecule, while the use of a multipole transferable aspherical atom model was adopted to achieve an accurate model, which had a minor disorder (12% occupancy) arising from a 45°rotation about the long axis of the cylinder. The exact locations of the nitrogen atoms were pinpointed from the short C-N bond lengths (1.33 Å) and the areas of high electron density corresponding to their lone pairs. Thus, with complete confidence about the precise atomic structure, Isobe et al. were able to bring a clear set of experimental results to the question of how pyridinic nitrogen-doping influences the properties of single-walled carbon nanotubes. The ability to study a pure molecular substance contrasts what is being learned using top-down methods, where carbon nanotubes, which themselves are complex mixtures, can only be chemically modified in an imprecise fashion. For example, nitrogen-doping can be achieved through exposure of nanotubes to nitrogen plasma, where the achievement of even modest levels of control with respect to regularity and the type of nitrogen-doping (graphitic, pyridinic or pyrrolic) is very difficult to achieve 6 . The main lesson learned from a comparison of the measured and calculated properties of the (12,12)-NpNT to those of the previously reported all-carbon pNT is that pyridinic nitrogen-doping results in a lowering of the energy of the LUMO, but does not affect the HOMO. Based on these findings, nanotubes doped with pyridinic nitrogen atoms can be expected to behave as n-type organic semiconductors.
Isobe's phenomenal (12,12)-NpNT has provided a solid basis for the development of a more detailed understanding of how pyridinic nitrogen-doping affects the properties of nanotubes and it is easy to imagine that further modifications to the nanotube structure should be achievable through the judicious choice of N BPin   building blocks and/or synthetic manipulation. A higher number of N atoms could be incorporated, thereby achieving much higher doping levels. The introduction of functional groups into the pores of the phenine nanotube through functionalization of either C or N sites would bring a range of opportunities for function. One could also consider patching the holes through chemical synthesis to give pristine, monodisperse nanotubes, with or without graphitic nitrogen atoms. The synthesis of longer tubes or even those with different roll-up motifs are further attractive possibilities, as is the capping of a tube at one end or both. In the broader picture, the prospect of exploiting the phenine concept to gain access to structure types that are either extremely difficult or downright impossible to construct using sp 2 -C atoms is a most exciting one. The possibilities are seemingly infinite.