Fig. 6: Schematic illustration of three distinct classes of extracellular vesicles – exosomes, shed microvesicles/microparticles and shed midbody remnants (sMB-Rs). | Communications Biology

Fig. 6: Schematic illustration of three distinct classes of extracellular vesicles – exosomes, shed microvesicles/microparticles and shed midbody remnants (sMB-Rs).

From: Secreted midbody remnants are a class of extracellular vesicles molecularly distinct from exosomes and microparticles

Fig. 6

Exosomes (class I EVs) are of endosomal origin (formed by invagination of multivesicular bodies (MVB)), shed microvesicles/ microparticles (class II extracellular vesicles) are formed via direct outward blebbing of plasma membrane and midbody remnants (MB-Rs) (class III extracellular vesicles) are generated by cytokinetic abscission of the interconnecting bridge between dividing daughter cells (post completion of cytokinesis). Current understanding of biophysical properties and stereotypic marker proteins for exosomes, sMVs (microparticles) and sMB-Rs are listed in the table. Centraspindlin complex proteins MKLP1 and RACGAP1 enable distinction of sMB-Rs from exosomes and sMVs.

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