Fig. 3: AIBP deficiency profoundly increases choroid sprouting and laser-induced CNV. | Communications Biology

Fig. 3: AIBP deficiency profoundly increases choroid sprouting and laser-induced CNV.

From: Combination of apolipoprotein-A-I/apolipoprotein-A-I binding protein and anti-VEGF treatment overcomes anti-VEGF resistance in choroidal neovascularization in mice

Fig. 3

a Representative images and quantification of microvascular sprouting area from Naxe−/− and WT adult mouse choroid explants. N = 3 choroid explants for WT, 4 for Naxe−/− mice. b Representative images of CNV lesions labeled by Alexa 568-isolectin on RPE-choroid flatmounts and quantification of CNV areas from Naxe−/− and WT adult mice. N = 33 laser spots per group. c Representative images of CNV lesions and quantification of CNV areas after intravitreal injection of a rabbit anti-AIBP antibody or a control IgG. N = 28 laser spots per group. Scale bar is 20 µm in b and c. Data represent mean ± SEM in ac. Statistical analysis was performed by two-tailed Student’s t-test.

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