a Schematic stepwise separation of two fluorescent dyes. T1: Cy5; T2: Cy3. Black anchors symbolize the methanol-responsive polymer backbone. b Photographs of tubes containing MeRPy-10 and a mixture of the dyes. MeRPy-10 was programmed to capture either T1 (upper path) or T2 (lower path). The target was then pulled down and isolated by the addition of methanol and a short spin-down. After separation, targets were released by TMSD.