Table 3 Descriptive characteristics of the study cohorts.

From: Analysis of genetically independent phenotypes identifies shared genetic factors associated with chronic musculoskeletal pain conditions

  Prevalence Sample size Age (mean ± SD) (years) BMI (mean ± SD) (kg m−2) Women (%)
Discovery cohorta (N = 265,000)
  Chronic back pain 17.9% Cases (N = 47,507) 57.65 (7.99) 28.33 (5.18) 53.88
Controls (N = 217,493) 57.26 (8.03) 27.15 (4.61) 54.32
  Chronic neck pain 16.3% Cases (N = 43,287) 57.73 (7.79) 27.90 (5.02) 53.84
Controls (N = 221,713) 57.25 (8.07) 27.25 (4.68) 54.32
  Chronic hip pain 9.2% Cases (N = 24,300) 59.15 (7.44) 28.91 (5.40) 54.35
Controls (N = 240,700) 57.15 (8.06) 27.20 (4.64) 54.23
  Chronic knee pain 17.5% Cases (N = 46,292) 58.61 (7.59) 29.18 (5.37) 54.12
Controls (N = 218,708) 57.06 (8.09) 26.97 (4.50) 54.27
Replication cohort (N=191,580)
 African ancestry (N = 7541)
  Chronic back pain 21.0% Cases (N = 1586) 53.77 (8.24) 30.62 (5.79) 54.50
Controls (N = 5955) 52.04 (8.00) 29.27 (5.13) 54.19
  Chronic neck pain 16.1% Cases (N = 1217) 54.38 (7.98) 30.06 (5.52) 54.35
Controls (N = 6324) 52.02 (8.04) 29.45 (5.25) 54.24
  Chronic hip pain 8.5% Cases (N = 641) 55.00 (7.91) 31.30 (6.14) 54.37
Controls (N = 6900) 52.16 (8.05) 29.39 (5.19) 54.25
  Chronic knee pain 20.4% Cases (N = 1539) 54.67 (8.30) 31.64 (6.11) 54.49
Controls (N = 6002) 51.82 (7.92) 29.01 (4.93) 54.20
 European ancestry (N = 174,831)
  Chronic back pain 18.0% Cases (N = 31,428) 57.62 (7.96) 28.36 (5.22) 54.05
Controls (N = 143,403) 57.26 (8.02) 27.14 (4.58) 54.28
  Chronic neck pain 16.3% Cases (N = 28,482) 57.82 (7.76) 27.92 (5.02) 54.27
Controls (N = 146,349) 57.23 (8.06) 27.25 (4.66) 54.24
  Chronic hip pain 9.2% Cases (N = 16,022) 59.26 (7.40) 28.86 (5.41) 54.61
Controls (N = 158,809) 57.13 (8.05) 27.21 (4.63) 54.20
  Chronic knee pain 17.3% Cases (N = 30,173) 58.71 (7.54) 29.24 (5.41) 54.27
Controls (N = 144,658) 57.04 (8.08) 26.97 (4.47) 54.23
 South Asian ancestryb (N = 9208)
  Chronic back pain 21.6% Cases (N = 1993) 54.66 (8.51) 27.76 (4.58) 54.29
Controls (N = 7215) 53.87 (8.47) 26.92 (4.23) 54.22
  Chronic neck pain 20.2% Cases (N = 1864) 54.65 (8.24) 27.43 (4.56) 54.31
Controls (N = 7344) 53.88 (8.53) 27.01 (4.25) 54.22
  Chronic hip pain 6.6% Cases (N = 610) 56.61 (8.21) 28.30 (4.90) 54.07
Controls (N = 8598) 53.86 (8.47) 27.01 (4.26) 54.25
  Chronic knee pain 20.1% Cases (N = 1850) 55.97 (8.23) 28.52 (4.86) 54.10
Controls (N = 7358) 53.55 (8.47) 26.74 (4.09) 54.27
  1. aDiscovery cohort comprised only individuals of European ancestry.
  2. bIndian, Pakistani, and Bangladeshi.