Fig. 8: Donor T-cell anti-tumor response to CDK4/6 inhibition correlates to canonical T-cell phenotypic markers. | Communications Biology

Fig. 8: Donor T-cell anti-tumor response to CDK4/6 inhibition correlates to canonical T-cell phenotypic markers.

From: A biomimetic assay platform for the interrogation of antigen-dependent anti-tumor T-cell function

Fig. 8

a Kinetic response of 6 normal human donor T-cells over 96 h under either high dose (50 μM) or low dose (5 μM) CDK4/6i treatment with matched peptides (CEF) or mismatched peptides (Scr). Data normalized to equivalent DMSO negative control samples; n = 3 independent experiments. b T-cell phenotyping data from five patients from a showing populations of CD8+-gated cells under all four CDK4/6i growth conditions. An independent sample t-test was used to calculate probability where *p < 0.05, **p < 0.01, ***p < 0.001 compared to Scr negative control samples; n = 3 independent experiments and error bars indicate standard deviation.

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