Fig. 5 | Communications Biology

Fig. 5

From: Metabolic gene alterations impact the clinical aggressiveness and drug responses of 32 human cancers

Fig. 5

a Clustering of HM (orange points) and LM (blue points) tumours based on mRNA transcript levels. b Clustering of 32 different cancer types based on mRNA transcript levels. Points are coloured according to the type of cancer they represent. For both plots (a and b), t-SNE was used to visualise the tumour classes using the exact algorithm and standardised Euclidean distance metric. c Three-dimensional plot of the HM/LM tumour supertype grouping based on mRNA transcript levels. d The integrated plot of mRNA expression correlations ordered by whether cancers belong to the HM or LM supertypes. From top to bottom, panels indicate: the tissue of origin; whether tumours belong to the HM or LM supertype; heatmap of inter-tumour linear Pearson’s correlation scores with increasing colour intensities denoting higher degrees of correlation

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