Fig. 5 | Communications Biology

Fig. 5

From: Enterococcus faecalis YM0831 suppresses sucrose-induced hyperglycemia in a silkworm model and in humans

Fig. 5

Inhibition of blood glucose increases by ingestion of E. faecalis YM0831 in a sucrose tolerance test in humans. Three sucrose tolerance tests were performed in each of the 14 healthy human subjects; a non-ingestion control, ingestion of bacterial cell suspension, and ingestion of heat-treated bacterial cell suspension. Subjects took the sample solution (YM0831 bacterial cells: 4 × 1010 cells/50 ml) suspended in saline 15 min before sucrose loading. Subsequently, the subjects drank 150 ml of 50% (w/v) sucrose solution. Blood glucose levels of the subjects were determined at 0, 15, 30, 45, 60, 90, and 120 min after sucrose challenge. Blood was collected from the fingertip and the blood sugar level was measured using a simple blood glucose meter. a Experimental schedule is shown. b Blood glucose levels in E. faecalis YM0831 cell suspension ingestion group (YM0831), autoclaved cell suspension ingestion group (autoclaved YM0831), and non-ingestion group (control) for each subject after sucrose loading are shown. *P < 0.017 after Bonferroni correction (paired Student’s t-test). c Sucrose tolerance tests in E. faecalis YM0831 cell suspension ingestion group (YM0831), autoclaved cell suspension ingestion group (Autoclaved YM0831), and non-ingestion group (control) are shown. *P < 0.017 after Bonferroni correction (paired Student’s t-test). Data represent mean ± SEM

Back to article page