Fig. 3 | Communications Biology

Fig. 3

From: Computational modeling of the olfactory receptor Olfr73 suggests a molecular basis for low potency of olfactory receptor-activating compounds

Fig. 3

Interaction fingerprints of 25 known Olfr73 agonists grouped in classes 1–5 according to Fig. 4. a In the interaction histogram, each contact of a particular residue with the ligand is indicated by a color. The color code distinguishes the residue location in a particular TM helix. Each class of compounds is separated by a horizontal gray line. b The pharmacophore model based on 25 known Olfr73 agonists. As a prototypical example, the position of isoeugenol in the Olfr73 binding pocket showing the interaction fingerprint. Assignments: H-bond donor (I), H-bond acceptor (II), hydrophobic moiety (III, IV, V, VI); polar residues (yellow), aromatic residues (cyan), hydrophobic residues (green)

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