Fig. 3 | Communications Biology

Fig. 3

From: Proliferative heterogeneity of murine epithelial cells in the adult mammary gland

Fig. 3

R-Spondin1-Wnt3 drives cells into a proliferative state. a Schematic of Rspo1-Wnt3 administration to mammary cells. Bar graphs indicate the proportion of cells in the different phases of the cell cycle within the (b) basal, (c) HR−, and d HR+ luminal colonies after 24 h treatment with DMSO or Rspo1-Wnt3 (mean ± SEM; n = 3). Two-way ANOVA analysis with Tukey’s multiple comparison test was used to determine changes in cell cycle proportions between DMSO and Rspo1-Wnt3 treatments within the different mammary epithelial cell types and changes of progenitor capacity between different cell cycle phases. *, **, *** represent statistical significant at P < 0.05, P < 0.01, and P < 0.001, respectively

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