Fig. 1 | Communications Biology

Fig. 1

From: Non-coding RNA fragments account for the majority of annotated piRNAs expressed in somatic non-gonadal tissues

Fig. 1

piRNAs in human plasma are non-coding RNA fragments. a Sequence logo showing 1 U bias in piRNA sequences in the RNAdb 2.0 database, and absence of such signature in the subset of sequences matching other known ncRNAs. For simplicity, only the first 15 bases are shown. b Read coverage of YRNAs (RNY4 and RNY1) in human plasma (SRR2496797) and human testis (ERA246774). The red and green bars represent the most and second-most abundant piRNAs found in human plasma in Freedman et al.18. The predicted secondary structure of RNY4 is shown, with the RNY4-derived piRNA highlighted in red. c Venn diagrams showing the 171,551 piRNAs in RNAdb 2.0, classified by either their 5′ start base or their identity to other ncRNAs. The piRNAs described in human plasma (blue) and human testis (orange) are overimposed, and enrichment scores (ES) were calculated as described in methods

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