Site-selective acylation of remote arene C(sp2)−H bonds is achieved through N-heterocyclic carbene organocatalysis. This catalytic transformation proceeds through a nitrogen radical-mediated pathway and enables the late-stage modification of drugs, amino acids and peptides under mild conditions.
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References
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This is a summary of: Li, Q.-Z. et al. Remote site-selective arene C–H functionalization enabled by N-heterocyclic carbene organocatalysis. Nat. Catal. https://doi.org/10.1038/s41929-024-01194-5 (2024).
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Organocatalytic acylation of remote arene C–H bonds. Nat Catal 7, 864–865 (2024). https://doi.org/10.1038/s41929-024-01195-4
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DOI: https://doi.org/10.1038/s41929-024-01195-4
