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Order matters in evolution


The understanding of protein evolution is a central challenge in biology. Now, the evolution of a β-lactamase in vitro reveals that the total effect of mutations can change the rate-limiting step of the catalytic mechanism.

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Fig. 1: Epistasis is rooted in changes in the catalytic cycle.


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Correspondence to Alejandro J. Vila.

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Dotta, G., Vila, A.J. Order matters in evolution. Nat Catal 7, 467–468 (2024).

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