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Metabolic engineering

Acetyl-CoA-independent malonyl-CoA biosynthesis

Malonyl-CoA is one of the fundamental building blocks for the synthesis of industrially or pharmaceutically important chemicals, but its biosynthesis via the innate acetyl-CoA carboxylation pathway remains slow and inefficient. Now, an artificial non-carboxylative malonyl-CoA biosynthetic pathway has been developed, significantly enhancing malonyl-CoA supply by boosting carbon and energy efficiency while sidestepping the inhibitions by host cell regulations.

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Fig. 1: The comparison between the natural pathway and the artificial pathway for malonyl-CoA supply.


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Correspondence to Dongsoo Yang.

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The author declares no competing interests.

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Yang, D. Acetyl-CoA-independent malonyl-CoA biosynthesis. Nat Catal 7, 347–349 (2024).

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