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Photoredox catalysis

Drug design via single-carbon atom insertion

While skeletal editing stands as a powerful approach for simplifying synthetic procedures and obtaining complex molecules, viable methodologies remain limited. Now, a smart photoredox protocol, involving the insertion of carbon atoms into the indene core, gives access to a wide library of functionalized naphthalenes.

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Fig. 1: Photoredox indene skeletal editing via single-carbon atom insertion.


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Correspondence to Paolo Costa.

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Sicignano, M., Costa, P. Drug design via single-carbon atom insertion. Nat Catal 7, 224–226 (2024).

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