The direct use of ammonia for asymmetric synthesis is highly sought after. Now, an efficient enantioselective carbene insertion into the N–H bond of ammonia has been developed, producing diverse valuable chiral α-amino acids.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Valera-Medina, A., Xiao, H., Owen-Jones, M., David, W. I. F. & Bowen, P. J. Prog. Energy Combust. Sci. 69, 63–102 (2018).
Bezdek, M. J., Guo, S. & Chirik, P. J. Science 354, 730–733 (2016).
Yin, Q., Shi, Y., Wang, J. & Zhang, X. Chem. Soc. Rev. 49, 6141–6153 (2020).
Li, M.-L., Pan, J.-B. & Zhou, Q.-L. Nat. Catal. https://doi.org/10.1038/s41929-022-00779-2 (2022).
Zhu, S.-F. & Zhou, Q.-L. Acc. Chem. Res. 45, 1365–1377 (2012).
Liang, Y., Zhou, H. & Yu, Z.-X. J. Am. Chem. Soc. 131, 17783–17785 (2009).
Ren, Y.-Y., Zhu, S.-F. & Zhou, Q.-L. Org. Biomol. Chem. 16, 3087–3094 (2018).
Li, M.-L., Yu, J.-H., Li, Y.-H., Zhu, S.-F. & Zhou, Q.-L. Science 366, 990–994 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Yang, L., Sun, J. Ammonia to chiral α-amino acid. Nat Catal 5, 471–472 (2022). https://doi.org/10.1038/s41929-022-00811-5
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41929-022-00811-5