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Mass-based biocatalyst metrics to guide protein engineering and bioprocess development

Metrics are a useful way to assess biocatalyst performance and, when compared to techno-economic targets, can help set goals for further enzyme and bioprocess research and development. Here, we outline some of the remaining challenges to ensure wider acceptance of this approach, both in industry and in academia.

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Fig. 1: Benchmarking cycle.


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Authors and Affiliations



J.W. and M.P.M. contributed equally to conceptualizing this work. J.W. wrote the original manuscript. M.P.M. proofread and edited this work and generated the figure.

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Correspondence to John M. Woodley.

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The authors declare no competing interests.

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Nature Catalysis thanks Bruno Bühler, Dunming Zhu and the other, anonymous, reviewer(s) for their contribution to the peer review of this work.

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Meissner, M.P., Woodley, J.M. Mass-based biocatalyst metrics to guide protein engineering and bioprocess development. Nat Catal 5, 2–4 (2022).

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