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HOMOGENEOUS CATALYSIS

The dawn of cross-coupling

Nature Catalysis volume 4, pages 732–733 (2021)Cite this article

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Methods for the direct one-step replacement of a hydrogen atom in a C–H bond by an organic functional group can create enormous possibilities for synthetic applications. On the way to solve this challenge, the discovery of the reaction of organopalladium complexes with olefins opened a new era in catalysis and organic chemistry.

Making C–C bonds and functionalizing organic molecules are the key chemical tools for the design and synthesis of new drugs, ranging from classical pharmaceutical substances to advanced personalized medicines. The ever-increasing demand for antibiotics and antiviral drugs highlights the need to find efficient and universal methodologies for quick access to diverse molecular structures. In addition to medicinal chemistry, selective construction of new C–C bonds is a special area of interest for the development of organic electronics, functional materials, agrochemicals and many paramount industrial applications.

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Fig. 1: Palladium-catalysed vinylic hydrogen substitution reaction.

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  1. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russia

    Valentine P. Ananikov

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  1. Valentine P. Ananikov
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Correspondence to Valentine P. Ananikov.

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Ananikov, V.P. The dawn of cross-coupling. Nat Catal 4, 732–733 (2021). https://doi.org/10.1038/s41929-021-00675-1

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