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The dawn of cross-coupling

Methods for the direct one-step replacement of a hydrogen atom in a C–H bond by an organic functional group can create enormous possibilities for synthetic applications. On the way to solve this challenge, the discovery of the reaction of organopalladium complexes with olefins opened a new era in catalysis and organic chemistry.

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Fig. 1: Palladium-catalysed vinylic hydrogen substitution reaction.


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Correspondence to Valentine P. Ananikov.

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Ananikov, V.P. The dawn of cross-coupling. Nat Catal 4, 732–733 (2021).

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