Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


Striking gold with chimeric proteins

The ability to control the subtle differences in reaction mechanisms and outcomes is an aspiration of many synthetic chemists. Now protein evolution has enabled the control of selectivity for hydroamination reactions catalysed by gold-based artificial metalloenzymes by favouring dual-gold catalysis over monomeric catalysis.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: The design and optimization of chimeric Sav-SOD proteins for selective gold catalysis.


  1. Schwizer, F. et al. Chem. Rev. 118, 142–231 (2018).

    Article  CAS  Google Scholar 

  2. Christoffel, F. et al. Nat. Catal. (2021).

  3. Zhou, Z. & Roelfes, G. Nat. Catal. 3, 289–294 (2020).

    Article  CAS  Google Scholar 

  4. Zhao, X., Rudolph, M. & Hashmi, A. S. Chem. Commun. 55, 12127–12135 (2019).

    Article  CAS  Google Scholar 

  5. Heinisch, T. & Ward, T. R. Acc. Chem. Res. 49, 1711–1721 (2016).

    Article  CAS  Google Scholar 

  6. Romney, D. K., Murciano-Calles, J., Wehrmüller, J. E. & Arnold, F. H. J. Am. Chem. Soc. 139, 10769–10776 (2017).

    Article  CAS  Google Scholar 

  7. Caldwell, S. J. et al. Proc. Natl. Acad. Sci. USA 117, 30362–30369 (2020).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Amanda G. Jarvis.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Jarvis, A.G. Striking gold with chimeric proteins. Nat Catal 4, 639–640 (2021).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing