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Polyketide Biosynthesis

An artificial pathway for polyketide biosynthesis

Polyketide synthases are multi-domain enzymes that catalyse the construction of many bioactive natural products. Now, some of the inefficiencies and limitations of these systems have been solved by designing an artificial pathway for carbon–carbon bond formation via iterative rounds of non-decarboxylative thio-Claisen reactions.

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Fig. 1: Natural and artificial pathways to polyketide products.


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Correspondence to Gavin J. Williams.

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Gayen, A.K., Nichols, L. & Williams, G.J. An artificial pathway for polyketide biosynthesis. Nat Catal 3, 536–538 (2020).

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