Polyketide synthases are multi-domain enzymes that catalyse the construction of many bioactive natural products. Now, some of the inefficiencies and limitations of these systems have been solved by designing an artificial pathway for carbon–carbon bond formation via iterative rounds of non-decarboxylative thio-Claisen reactions.
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References
- 1.
Kalkreuter, E. & Williams, G. J. Curr. Opin. Microbiol. 45, 140–148 (2018).
- 2.
Wu, X. & Huang, T. Future Med. Chem. 12, 533–561 (2020).
- 3.
Tan, Z., Clomburg, J. M., Cheong, S., Qian, S. & Gonzalez, R. Nat. Catal. https://doi.org/10.1038/s41929-020-0471-8 (2020).
- 4.
Haapalainen, A. M., Gitte, M. & Rik, K. W. Trends Biochem. Sci. 31, 64–71 (2006).
- 5.
Tang, S. et al. J. Am. Chem. Soc. 135, 10099–10103 (2013).
- 6.
Kalkreuter, E., CroweTipton, J. M., Lowell, A. N., Sherman, D. H. & Williams, G. J. J. Am. Chem. Soc. 141, 1961–1969 (2019).
- 7.
Bonk, B. M., Tarasova, Y., Hicks, M. A., Tidor, B. & Prather, K. L. J. Biotechnol. Bioeng. 115, 2167–2182 (2018).
- 8.
Blaisse, M. R., Fu, B. & Chang, M. C. Y. Biochemistry 57, 3155–3166 (2018).
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Gayen, A.K., Nichols, L. & Williams, G.J. An artificial pathway for polyketide biosynthesis. Nat Catal 3, 536–538 (2020). https://doi.org/10.1038/s41929-020-0483-4
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