Polyketide synthases are multi-domain enzymes that catalyse the construction of many bioactive natural products. Now, some of the inefficiencies and limitations of these systems have been solved by designing an artificial pathway for carbon–carbon bond formation via iterative rounds of non-decarboxylative thio-Claisen reactions.
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The authors declare no competing interests.
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Gayen, A.K., Nichols, L. & Williams, G.J. An artificial pathway for polyketide biosynthesis. Nat Catal 3, 536–538 (2020). https://doi.org/10.1038/s41929-020-0483-4