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PEPTIDE MACROCYCLIZATION

Cycling back to biocatalysis

Macrocyclic peptide natural products are important medicinal compounds. The catalytic properties of an unusual peptide cyclase enzyme have recently been described — providing opportunities for the engineering and synthesis of structurally complex peptides with novel biological activities.

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Fig. 1: Overview of surugamide A biosynthetic pathway.

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Correspondence to Christopher J. Thibodeaux.

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Attia, M.A., Thibodeaux, C.J. Cycling back to biocatalysis. Nat Catal 3, 476–477 (2020). https://doi.org/10.1038/s41929-020-0469-2

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