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Chiral macrocycles

Synthetic complexity created by lipases

Nature Catalysis volume 3, pages 335–336 (2020)Cite this article

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The chemoenzymatic potential for the construction of complex chiral molecules has not been fully explored. Now, Candida antarctica lipase B has been used to synthesize complex functionalized planar chiral macrocycles, providing a platform for the efficient and sustainable preparation of molecules that are of particular interest in drug discovery.

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Fig. 1: Biocatalytic synthesis of planar chiral macrocycles.

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  1. Department of Biocatalysis, Institute of Catalysis, CSIC, Madrid, Spain

    Jose M. Palomo

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  1. Jose M. Palomo
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Correspondence to Jose M. Palomo.

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Palomo, J.M. Synthetic complexity created by lipases. Nat Catal 3, 335–336 (2020). https://doi.org/10.1038/s41929-020-0453-x

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