A single amino acid enzyme

Article metrics

Enzymes require many, often hundreds, of amino acid residues arranged in a protein fold to promote catalysis. Now, self-assembly of a single amino acid — phenylalanine — in the presence of zinc is shown to form supramolecular structures that promote hydrolysis better than natural enzymes on a weight basis.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    Zozulia, O., Dolan, M. A. & Korendovych, I. V. Chem. Soc. Rev. 47, 3621–3639 (2018).

  2. 2.

    Makam, P. et al. Nat. Catal. (2019).

  3. 3.

    Krishnamurthy, V. M. et al. Chem. Rev. 108, 946–1051 (2008).

  4. 4.

    Adler-Abramovich, L. et al. Nat. Chem. Biol. 8, 701–706 (2012).

  5. 5.

    Zastrow, M. L., Peacock, A. F. A., Stuckey, J. A. & Pecoraro, V. L. Nat. Chem. 4, 118–123 (2012).

  6. 6.

    Cobb, A. K. & Pudritz, R. E. Astophys. J. 783, 140 (2014).

Download references

Author information

Correspondence to Olga V. Makhlynets or Ivan V. Korendovych.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Makhlynets, O.V., Korendovych, I.V. A single amino acid enzyme. Nat Catal 2, 949–950 (2019) doi:10.1038/s41929-019-0379-3

Download citation