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BIOORTHOGONAL CATALYSIS

Exosomes for cell-targeted bioorthogonal catalysis

Nature Catalysis volume 2, pages 837–838 (2019)Cite this article

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Transition metal-catalysed bioorthogonal reactions are severely hindered in biomedical applications, mainly due to a lack of target specificity. Now, research shows that a trojan exosome vesicle can deliver a palladium catalyst specifically to progenitor cells for bioorthogonal catalysis, allowing localized prodrug activation.

Bioorthogonal chemistry refers to chemical reactions that proceed in complex biological systems without disturbing normal physiological processes1. It has emerged as a powerful toolkit for monitoring and controlling the manipulation of targeted biological processes in the biological milieu2,3. Targeted bioorthogonal catalysis has attracted tremendous interests for in situ drug synthesis. However, transition-metal-catalysed bioorthogonal reactions are usually modulated by an extrinsic stimulus4 in living cells because of their lack of cell-specificity and off-target interference.

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Fig. 1: Scheme of preparation and intracellular catalysis of Pd-loaded exosomes.

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Authors and Affiliations

  1. Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, China

    Zhi Du & Xiaogang Qu

  2. University of Chinese Academy of Sciences, Beijing, China

    Zhi Du

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  1. Zhi Du
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  2. Xiaogang Qu
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Correspondence to Xiaogang Qu.

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Du, Z., Qu, X. Exosomes for cell-targeted bioorthogonal catalysis. Nat Catal 2, 837–838 (2019). https://doi.org/10.1038/s41929-019-0350-3

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  • DOI: https://doi.org/10.1038/s41929-019-0350-3

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