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Exosomes for cell-targeted bioorthogonal catalysis

Transition metal-catalysed bioorthogonal reactions are severely hindered in biomedical applications, mainly due to a lack of target specificity. Now, research shows that a trojan exosome vesicle can deliver a palladium catalyst specifically to progenitor cells for bioorthogonal catalysis, allowing localized prodrug activation.

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Fig. 1: Scheme of preparation and intracellular catalysis of Pd-loaded exosomes.


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Correspondence to Xiaogang Qu.

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Du, Z., Qu, X. Exosomes for cell-targeted bioorthogonal catalysis. Nat Catal 2, 837–838 (2019).

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