BIOCATALYSIS

Enzyme catalysis under pressure

A strategy using pressure was devised to structurally identify conformational transitions in protein ensembles, allowing the rational prediction of mutations that induce pressure-driven enzyme activation. These results highlight the power of flexibility–function analyses in protein engineering design and applications.

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Fig. 1: Rational prediction of mutations that induce pressure-driven enzyme activation.

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Correspondence to Nicolas Doucet.

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Doucet, N. Enzyme catalysis under pressure. Nat Catal 2, 646–647 (2019). https://doi.org/10.1038/s41929-019-0326-3

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