Glyco-enzymatic cascades get protection

The biological functions of glycan motifs such as the Lewis blood antigens are often defined by their precise multivalent presentation on complex glycoconjugates, making synthesis particularly challenging. Access to a number of positionally defined Lewis motifs on natural polysaccharide scaffolds has now been achieved using bacterial glycosyltransferases.

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Fig. 1: Enzymatic site-specific fucosylation of poly-LacNAc.


  1. 1.

    Nycholat, C. M. et al. Angew. Chem. Int. Ed. 51, 4860–4863 (2012).

  2. 2.

    Ye, J. et al. Nat. Catal. (2019).

  3. 3.

    Zervosen, A. & Elling, L. J. Am. Chem. Soc. 118, 1836–1840 (1996).

  4. 4.

    Zhang, J. et al. Angew. Chem. Int. Ed. 57, 16638–16642 (2018).

  5. 5.

    Gray, C. J. et al. Anal. Chem. 89, 4540–4549 (2017).

  6. 6.

    Hahm, H. S. et al. Chem 2, 114–124 (2017).

  7. 7.

    Wang, Z. et al. Science 341, 379–383 (2013).

  8. 8.

    Varki, A. et al. Glycobiology 25, 1323–1324 (2015).

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Correspondence to Sabine L Flitsch.

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Huang, K., Flitsch, S.L. Glyco-enzymatic cascades get protection. Nat Catal 2, 479–480 (2019).

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