The biological functions of glycan motifs such as the Lewis blood antigens are often defined by their precise multivalent presentation on complex glycoconjugates, making synthesis particularly challenging. Access to a number of positionally defined Lewis motifs on natural polysaccharide scaffolds has now been achieved using bacterial glycosyltransferases.
This is a preview of subscription content, access via your institution
Access options
Access Nature and 54 other Nature Portfolio journals
Get Nature+, our best-value online-access subscription
$29.99 / 30 days
cancel any time
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Nycholat, C. M. et al. Angew. Chem. Int. Ed. 51, 4860–4863 (2012).
Ye, J. et al. Nat. Catal. https://doi.org/10.1038/s41929-019-0281-z (2019).
Zervosen, A. & Elling, L. J. Am. Chem. Soc. 118, 1836–1840 (1996).
Zhang, J. et al. Angew. Chem. Int. Ed. 57, 16638–16642 (2018).
Gray, C. J. et al. Anal. Chem. 89, 4540–4549 (2017).
Hahm, H. S. et al. Chem 2, 114–124 (2017).
Wang, Z. et al. Science 341, 379–383 (2013).
Varki, A. et al. Glycobiology 25, 1323–1324 (2015).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Huang, K., Flitsch, S.L. Glyco-enzymatic cascades get protection. Nat Catal 2, 479–480 (2019). https://doi.org/10.1038/s41929-019-0294-7
Published:
Issue Date:
DOI: https://doi.org/10.1038/s41929-019-0294-7
