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Chiral γ-lactam synthesis via asymmetric C–H amidation

Nature Catalysisvolume 2pages182183 (2019) | Download Citation

The asymmetric synthesis of chiral γ-lactams is difficult and laborious; typically requiring pre-functionalization of starting materials. Now, a highly efficient alternative approach employing direct C−H amidation via chiral hydrogen-bond-donor catalysts has been developed.

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Affiliations

  1. State Key Laboratory of Physical Chemistry of Solid Surfaces, Key Laboratory for Chemical Biology of Fujian Province and College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China

    • Tong-De Tan
    •  & Long-Wu Ye

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Correspondence to Long-Wu Ye.

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https://doi.org/10.1038/s41929-019-0236-4

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