The asymmetric synthesis of chiral γ-lactams is difficult and laborious; typically requiring pre-functionalization of starting materials. Now, a highly efficient alternative approach employing direct C−H amidation via chiral hydrogen-bond-donor catalysts has been developed.
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Tan, TD., Ye, LW. Chiral γ-lactam synthesis via asymmetric C–H amidation. Nat Catal 2, 182–183 (2019). https://doi.org/10.1038/s41929-019-0236-4
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DOI: https://doi.org/10.1038/s41929-019-0236-4
