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Challenges and outlook for catalytic direct amidation reactions

Nature Catalysis volume 2, pages 98–102 (2019)Cite this article

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Establishing an efficient catalytic system for direct amidation reactions has remained a formidable challenge for years. This Comment will focus on potential new directions in the hope of moving this field forward.

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Fig. 1: Potential bifunctional catalytic models and the ester-mediated amidation.
Fig. 2: A potential catalytic system using a regenerable coupling reagent.
Fig. 3: Possible new directions in catalytic direct amidation.

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  1. School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China

    Xiao Wang

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Wang, X. Challenges and outlook for catalytic direct amidation reactions. Nat Catal 2, 98–102 (2019). https://doi.org/10.1038/s41929-018-0215-1

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