The biosynthesis of the pharmacophoric tetrahydropyran of the clinically important antibiotic mupirocin remained enigmatic for a long time. Now, research shows that this ring is formed by a unique epoxidation–epoxide-opening cascade starting from a non-activated alkane.
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Hahn, F. Heterocycle biosynthesis via C–H functionalization. Nat Catal 1, 905–906 (2018). https://doi.org/10.1038/s41929-018-0194-2
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DOI: https://doi.org/10.1038/s41929-018-0194-2