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Celebrating 100 years of the Rosenmund reaction

This year marks a century since the pioneering work leading to what is now known as the Rosenmund reduction. We celebrate this landmark, reflecting upon the evolution of synthetic methodologies for reductive aldehyde synthesis from carboxylic acid derivatives and highlighting modern, improved strategies.

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Fig. 1: Classic strategies for synthesis of aldehydes from carboxylic acids.
Fig. 2: Overview of aldehyde reductive synthesis.
Fig. 3: Modern applications of the Rosenmund reduction.

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Correspondence to Joakim Bergman.

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Iosub, A.V., Wallentin, CJ. & Bergman, J. Celebrating 100 years of the Rosenmund reaction. Nat Catal 1, 645–648 (2018). https://doi.org/10.1038/s41929-018-0143-0

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