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Celebrating 100 years of the Rosenmund reaction

Nature Catalysis volume 1, pages 645–648 (2018)Cite this article

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This year marks a century since the pioneering work leading to what is now known as the Rosenmund reduction. We celebrate this landmark, reflecting upon the evolution of synthetic methodologies for reductive aldehyde synthesis from carboxylic acid derivatives and highlighting modern, improved strategies.

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Fig. 1: Classic strategies for synthesis of aldehydes from carboxylic acids.
Fig. 2: Overview of aldehyde reductive synthesis.
Fig. 3: Modern applications of the Rosenmund reduction.

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Authors and Affiliations

  1. Cardiovascular, Renal and Metabolism IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden

    Andrei V. Iosub & Joakim Bergman

  2. Department of Chemistry and Molecular Biology, Gothenburg University, Gothenburg, Sweden

    Carl-Johan Wallentin

Authors
  1. Andrei V. Iosub
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  2. Carl-Johan Wallentin
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  3. Joakim Bergman
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Correspondence to Joakim Bergman.

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Iosub, A.V., Wallentin, CJ. & Bergman, J. Celebrating 100 years of the Rosenmund reaction. Nat Catal 1, 645–648 (2018). https://doi.org/10.1038/s41929-018-0143-0

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