The carboxylation of aromatic compounds with CO2 is an attractive reaction, albeit limited in scope. Now, bulky ligands in a Rh(II) catalysed C–H carboxylation of 2-arylphenols are shown to override the standard ortho/para Kolbe–Schmitt-type regioselectivity allowing instead carboxylation at 2’.
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Spencer, A., Lopez-Rodriguez, R. & Larrosa, I. Two prime or not two prime. Nat Catal 1, 381–382 (2018). https://doi.org/10.1038/s41929-018-0097-2
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DOI: https://doi.org/10.1038/s41929-018-0097-2